Routine pediatric immunizations

Overview of Treatment

Children's routine vaccination is a systematic preventive medical measure that induces active immunity in the body through vaccination, aiming to prevent infections from various highly contagious diseases. This schedule primarily targets the immune system characteristics during childhood growth and development, following the vaccination timetable recommended by the World Health Organization and national health authorities, effectively reducing severe cases, complications, and mortality.

Vaccination not only protects individual children but also reduces disease transmission within the community through "herd immunity." This program applies to children aged 0 to 18 who have not been vaccinated or have incomplete vaccination, requiring phased immunization according to the vaccination manual published by the health department.

Types and Mechanisms of Vaccines

Vaccines are mainly divided into inactivated vaccines, attenuated live vaccines, subunit vaccines, and other types. Inactivated vaccines contain pathogens that have lost infectivity, such as the pertussis vaccine; attenuated live vaccines use weakened pathogens, such as the measles vaccine. These antigen components stimulate T cells and B cells to produce memory immune responses, enabling rapid activation of protective antibodies upon exposure to real pathogens.

Modern vaccine technology has developed new types such as virus-like particle vaccines and mRNA vaccines, which can precisely trigger specific antigen responses. Usually, it takes 2 to 4 weeks after vaccination to develop sufficient immunity, and some vaccines require booster doses to extend protection.

Indications

This schedule provides immunization protection against 12 highly lethal infectious diseases, including:

  • Whooping cough, tetanus, diphtheria
  • Rotavirus, Haemophilus influenzae type b infections
  • Measles, mumps, rubella
  • Hepatitis B, chickenpox, meningococcal meningitis

Eligible recipients include BCG vaccination within 24 hours of birth, and expanded vaccination programs according to monthly age progression, effectively blocking vertical transmission and community spread.

Administration and Dosage

Administration is primarily via intramuscular or subcutaneous injection; some vaccines, such as oral rotavirus vaccines, are given through the digestive tract. Dosage adjustments depend on age, weight, and vaccine type, for example:

  • One dose of BCG at birth
  • Three basic doses plus booster for DTaP vaccine
  • 2 to 3 doses for HPV vaccine

The vaccination schedule strictly follows the "Immunization Manual," with some vaccines requiring intervals of 1 to 2 months to ensure adequate antibody development.

Benefits and Advantages

Vaccination can produce the following key benefits: 1. Reduce infection rates by 80-95%, 2. Prevent acquired immunodeficiency, 3. Avoid excessive use of medical resources. For example, when measles vaccination coverage reaches 95%, herd immunity is established, blocking community transmission.

This approach offers cost-effectiveness; WHO statistics show that every 1 USD spent on vaccines can save 10-16 USD in medical expenses. Digital vaccination record systems further ensure vaccination completeness.

Risks and Side Effects

Common local reactions include redness and swelling at the injection site, low-grade fever (below 38°C), which usually resolves within 2-3 days. Severe allergic reactions (such as anaphylactic shock) are rare, occurring at a rate of less than one in a million, typically within 30 minutes of vaccination.

Very rare but noteworthy complications include:

  • Ulceration at the BCG vaccination site
  • Post-measles vaccine low-grade fever and febrile seizures
  • Guillain-Barré syndrome triggered by tetanus toxoid

Precautions and Contraindications

Before vaccination, inform healthcare providers of: 1. Severe allergy history, 2. Immunodeficiency history, 3. Current fever or acute illness. Contraindications include:

  • Allergy to vaccine components (e.g., neomycin, kanamycin)
  • Congenital immunodeficiency
  • Recent blood product transfusions

Special populations such as preterm infants or those with congenital heart disease should follow individual medical assessments.

Interactions with Other Treatments

Vaccines do not have direct drug interactions with antibiotics or antipyretics, but immunosuppressants (such as corticosteroids) may reduce immune responses. Recommendations include:

  • Spacing 2 weeks between oral polio vaccine and intestinal probiotics
  • Postponing live vaccines during chemotherapy
  • Avoiding other vaccines within 48 hours after vaccination

Simultaneous administration of multiple vaccines does not increase serious side effects but should follow recommended intervals.

Effectiveness and Evidence

Global data show that pertussis vaccine provides 90% protection, and the polio vaccine has reduced cases worldwide by 99%. Since Taiwan incorporated the Haemophilus influenzae type b vaccine into the public vaccination program in 1998, related meningitis cases have decreased by 95%.

Vaccine efficacy is evaluated based on "seroconversion rates" and "herd coverage." WHO statistics indicate that vaccination programs have reduced mortality in children under 5 by 40%. However, the match between vaccine strains and circulating virus strains influences protective efficacy.

Alternatives

For those with severe allergies to vaccine components, consider: 1. Passive immunity via immunoglobulin injections (providing immediate protection), 2. Delaying vaccination until allergens are eliminated. These alternatives are short-term measures and cannot replace active immunity.

In special cases such as preterm infants, doses can be adjusted based on weight; for those with congenital immunodeficiency, alternative options such as inactivated vaccines should be evaluated.

 

Frequently Asked Questions

Do I need to adjust diet or sleep before vaccination?

There is no need to fast or alter sleep patterns before vaccination, but it is recommended that children maintain their usual routines and avoid vaccination when tired or ill. If the child has a fever or acute illness, postpone vaccination until recovery to ensure vaccine efficacy and reduce discomfort.

What should I do if redness, swelling, or fever occurs at the injection site?

Minor redness and swelling can be relieved with cold compresses or a clean towel, and scratching the site should be avoided. For fever, use antipyretics recommended by a doctor based on weight, and ensure rest and hydration. If fever persists beyond 48 hours or swelling enlarges, seek medical attention promptly.

If I miss the scheduled vaccination, do I need to restart the entire schedule?

No, simply follow the current age and vaccination record, and add the missed doses according to the supplementary schedule provided by the health authorities. It is advisable to contact a healthcare provider to adjust the schedule promptly, but delays do not compromise the immunity already established.

Does simultaneous vaccination affect safety or effectiveness?

The vaccination schedule has been designed considering the safety of administering multiple vaccines together, which does not reduce immune efficacy. WHO recommends timely vaccination to prevent diseases, but if parents are concerned about existing health conditions, they should discuss adjustments with their doctor.

How long does protection last after completing the primary series? Are booster doses necessary?

Protection duration varies by vaccine; for example, Haemophilus influenzae type b (Hib) vaccine lasts about 5 years, while tetanus requires booster every 10 years. Doctors will advise eligible individuals to receive booster doses based on vaccine type and epidemiological data to extend immunity.