Lurasidone (brand name Latuda) is a second-generation antipsychotic medication primarily used for the treatment of schizophrenia and manic episodes in bipolar disorder. It works by modulating dopamine and serotonin transmission in the brain, effectively improving symptoms such as hallucinations, delusions, and emotional instability. This medication is formulated as an oral tablet and should be used according to a physician's instructions.
Compared to traditional antipsychotics, Lurasidone carries a lower risk of extrapyramidal symptoms and long-term movement disorders but may increase the risk of metabolic abnormalities. Its mechanism of action involves selective antagonism of dopamine D2, serotonin 5-HT7, and 5-HT2A receptors, providing a comprehensive effect in controlling both positive symptoms (such as hallucinations) and negative symptoms (such as emotional flatness).
The generic name is Lurasidone, and the main brand name is Latuda. The medication may have different brand names in various countries, but the generic name remains consistent. Patients should verify that the name on the medication packaging matches the prescription from their healthcare provider.
It belongs to the class of second-generation antipsychotics (atypical antipsychotics), chemically classified as a dopamine D2 and serotonin receptor antagonist. This class of drugs generally offers a better side effect profile compared to first-generation antipsychotics but should be prescribed based on individual patient conditions.
The primary approved uses include:
In Taiwan, this medication requires a prescription from a licensed physician and should not be self-adjusted in dosage or treatment duration.
Mild side effects include:
Serious side effects necessitate immediate discontinuation and medical attention:
Contraindications: Patients allergic to Lurasidone or with severe cardiac arrhythmias such as long QT syndrome should not use this medication. Prior to use, patients should inform their healthcare provider of any cardiovascular disease history or drug allergies.
Pregnant women or those planning pregnancy should weigh the risks and benefits, as the drug may affect fetal development. It is not recommended during breastfeeding due to potential secretion into breast milk.
Contraindicated interactions:
Patients should inform their healthcare provider of all concomitant medications, including herbal supplements or dietary products, such as St. John’s Wort, which may enhance sedative effects.
The initial dose is usually 20-40 mg daily, adjusted based on efficacy and tolerability, with a maximum dose generally not exceeding 80 mg/day. Tablets should be swallowed whole, not chewed or crushed. Taking the medication at a fixed time, preferably after meals, can reduce gastrointestinal discomfort.
Patients with liver or kidney impairment should reduce the dose; for moderate hepatic impairment, the maximum dose is 40 mg daily. Children and adolescents aged 13-17 are only indicated for bipolar disorder treatment, with doses adjusted according to body weight.
If a dose is missed and more than 6 hours remain before the next scheduled dose, take it as soon as possible. If it is close to the next dose time, skip the missed dose and resume the regular schedule. Do not double the dose to make up for a missed one.
Overdose may cause confusion, muscle rigidity, drowsiness, or arrhythmias. Immediate medical attention is required, bringing the medication packaging. Activated charcoal may be used to adsorb residual drug, and ECG monitoring is recommended. Severe overdose may necessitate hospitalization for observation.
Symptoms such as hypotension and respiratory depression should be managed with supportive care, including airway management or intravenous glucose infusion.
It is recommended to take Lurasidone immediately after a meal to enhance absorption efficiency. A high-fat meal may increase blood levels of the drug but is not mandatory. Patients should take the medication consistently at the same time and follow their healthcare provider’s instructions regarding dosage and dietary intake.
What should I do if I experience drowsiness or weight gain while using Lurasidone?Drowsiness is a common initial side effect and usually improves after a few weeks. If severe, discuss dosage adjustment with your doctor. Weight gain may be related to metabolic syndrome; regular monitoring of weight and blood glucose levels is advised, along with a low-calorie diet and regular exercise to manage it.
Are there any drug interactions I should be aware of when combining Lurasidone with other psychiatric medications?Using with other dopamine antagonists or anticholinergic drugs may increase side effects such as akathisia or cognitive impairment. Combining with antacids (such as aluminum/magnesium-based) may reduce efficacy; it is recommended to take them at least 2 hours apart. Always inform your healthcare provider of all medications you are taking.
What blood tests should I undergo during Lurasidone treatment?Long-term use may affect blood glucose, lipid profile, and liver function; regular monitoring every 3-6 months is recommended. Patients with a history of arrhythmias may require ECG monitoring of QT interval. During initial treatment, white blood cell counts should also be checked to exclude hematological abnormalities.
Can I suddenly stop taking Lurasidone?No, abrupt discontinuation can trigger withdrawal reactions such as anxiety or symptom rebound. Physicians typically develop a gradual tapering plan and closely monitor symptom changes. If intolerable side effects occur, contact your healthcare provider immediately rather than stopping the medication on your own.
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