Rosacea - Overview

Rosacea is a common chronic skin condition primarily affecting the central face, characterized by recurrent redness and vascular dilation. It is most frequently seen in adults over 30 years old, with a higher prevalence in women, although men may experience more severe symptoms. While not life-threatening, its impact on appearance and psychological well-being should not be underestimated.

Modern medical research indicates that the etiology of rosacea involves multiple interacting factors, including genetic predisposition, environmental triggers, and immune system abnormalities. Recent clinical statistics suggest that approximately 16 million people worldwide suffer from this condition, yet over 50% of patients remain undiagnosed. This article provides a comprehensive overview of the causes, symptoms, diagnosis, and treatment options for this common dermatological disorder.

Causes and Risk Factors

The pathogenesis of rosacea is not fully understood, but several key factors have been identified. Genetic studies show that individuals with a family history of rosacea have a 2-3 times higher risk of developing the disease. Abnormal skin barrier function is also a significant factor, as decreased hydration of the stratum corneum makes skin more susceptible to external stimuli. Additionally, overgrowth of certain microorganisms such as *Demodex* mites and *Staphylococcus epidermidis* may trigger chronic inflammatory responses.

Environmental factors play a crucial role in disease onset, including:

  • Ultraviolet exposure: prolonged sun exposure exacerbates redness
  • Temperature changes: extreme heat or cold stimuli
  • Chemical irritants: cosmetics containing alcohol or fragrances
  • Dietary factors: spicy foods, high-histamine foods (such as cheese and pickled products)

Immune system abnormalities are also central, with overactivation of T lymphocytes leading to persistent vasodilation. Recent studies have also found an abnormal increase in *Demodex* mite populations within sebaceous glands, which may be associated with worsening symptoms.

Symptoms

Rosacea symptoms can be categorized into core symptoms and subtype manifestations. Early-stage common symptoms during the "flush" phase include:

  • Transient facial redness in the central face, worsened by touch or temperature changes
  • Visible telangiectasias forming permanent erythema
  • Increased sensitivity to hot drinks, hot foods, or emotional stress

As the disease progresses, different subtypes may appear:

  • Papulopustular: red papules and pustules resembling acne but without blackheads
  • Ocular rosacea: eyelid redness, swelling, dryness, or gritty sensation
  • Nasal phymatous: hypertrophy of nasal tissue forming a bulbous nose, more common in male patients

The severity of symptoms is closely related to lifestyle factors, with triggers such as stress, alcohol, or specific foods often precipitating acute flare-ups. Notably, about 30% of patients also experience ocular symptoms, requiring collaboration between dermatologists and ophthalmologists.

Diagnosis

Diagnosis of rosacea primarily relies on clinical presentation, but other conditions such as acne vulgaris or rhinophyma must be excluded. Dermatologists typically perform visual inspection, observing symmetrical erythema in the three facial zones (forehead, cheeks, nose). Recent diagnostic criteria categorize symptoms into core and secondary features, with core symptoms including persistent erythema and flushing triggered by certain factors.

The diagnostic process may include:

  1. Detailed medical history: documenting symptom duration and triggers
  2. Dermatoscopy: observing telangiectasias and skin thickness changes
  3. Excluding other diseases: such as systemic lupus erythematosus or contact dermatitis

In special cases, skin biopsy may be performed to rule out other chronic skin conditions. Accurate diagnosis depends heavily on clinician experience, so it is recommended to seek care at specialized dermatology clinics.

Treatment Options

Treatment strategies should be tailored based on symptom severity. Mild cases often respond well to topical medications. Topical treatments include:

  • Antibiotic creams: such as metronidazole or ivermectin
  • Retinoids: to improve keratinocyte metabolism and reduce inflammation
  • Anti-inflammatory gels: such as clindamycin gel

Moderate to severe cases may require oral medications, including:

  • Oral antibiotics: such as tetracyclines, with attention to antibiotic resistance
  • Anti-inflammatory agents: such as isotretinoin for acute flare management
  • Laser therapy: pulsed dye laser can improve vascular dilation

Emerging treatments like photodynamic therapy, which combines specific photosensitizing agents with particular wavelengths of light, can precisely target inflammatory cells. Treatment plans should be complemented with daily skin care, with physicians generally recommending non-irritating products and strict avoidance of triggers.

Prevention

While rosacea cannot be completely prevented, routine skin care can reduce flare frequency. It is recommended to use fragrance-free, low-irritant cleansers, with no more than three daily applications. When outdoors, use sunscreens with SPF 30 or higher and physical barriers such as wide-brimmed hats.

Lifestyle modifications are crucial for disease control:

  • Avoid high-temperature environments: hot foods, hot water washing, saunas
  • Diet management: reduce spicy foods and alcohol, especially red wine
  • Stress management: stress reduction courses or mindfulness practices can decrease flare-ups
  • Cosmetic choices: avoid products containing alcohol or fruit acids

Regular skin examinations can help detect early changes. It is advised to undergo professional skin assessments every 3-6 months. Patients should keep a personalized trigger diary to assist physicians in adjusting treatment plans.

When Should You See a Doctor?

If persistent facial redness of unknown cause lasts longer than six weeks, seek medical attention promptly. If symptoms interfere with daily social activities or if warning signs appear, immediate consultation is necessary:

  • Expansion of redness to ears or neck
  • Painful nodules or pustules
  • Ocular symptoms causing blurred vision
  • Reduced effectiveness of current treatments

It is recommended to use the "Rosacea Severity Score" for self-assessment. When the total score exceeds 8, a professional diagnosis should be scheduled. Regular follow-up can effectively control the condition and prevent progression to late-stage nasal tissue hypertrophy.

 

Frequently Asked Questions

How to distinguish rosacea from general facial flushing?

Rosacea-related facial redness usually lasts longer (more than 10 minutes) and may be accompanied by telangiectasias or papules. If flushing occurs briefly after cold or hot stimuli and without skin lesions, it may be a transient response. Observe whether persistent erythema or pus bumps are present; if in doubt, consult a dermatologist for diagnosis.

Which ingredients in daily skincare products may trigger rosacea worsening?

Ingredients such as alcohol, fruit acids, and salicylic acid can be irritating and may worsen symptoms. It is recommended to choose fragrance-free, hypoallergenic formulations, and products labeled as "rosacea-friendly" or "suitable for sensitive skin." New products should be patch-tested on a small area first, observing for 24-48 hours for adverse reactions.

What are the indications and potential risks of oral medication for rosacea?

Oral antibiotics (such as tetracyclines) or pulsed light therapy may be used for moderate to severe cases when topical treatments are insufficient. Long-term antibiotic use can lead to gut flora imbalance or antibiotic resistance, so medical supervision and regular assessment are necessary. Severe cases might require immunomodulators, with careful evaluation of liver and kidney function.

What dietary restrictions or recommendations are advised for rosacea patients?

Spicy foods, alcohol, and high-calorie diets may trigger redness; reducing intake is advised. A gentle diet rich in antioxidants from fruits and vegetables (such as blueberries and leafy greens) may help alleviate symptoms. Caffeine effects vary among individuals; some patients may need to avoid it, adjusting based on personal response.

How effective is laser treatment for facial redness, and what precautions should be taken?

Pulsed dye laser or 595nm dye laser can significantly improve facial redness. Typically, 3-6 sessions are required, spaced 4-6 weeks apart. Post-treatment, strict sun protection and avoidance of irritating skincare are essential. Mild swelling may occur initially; severe reactions require concurrent medication. Patients should inform their doctor of their medical history, especially if they have a history of vascular anomalies, for proper assessment.

Rosacea