Asthma - Diagnosis

The diagnosis of asthma requires a combination of medical history analysis, symptom observation, and objective examination results. Doctors typically start from the patient's respiratory manifestations, ruling out other possible diseases before confirming whether the diagnostic criteria for asthma are met. The diagnostic process may include medical history inquiry, physical examination, and multiple functional tests to ensure accuracy.

Early diagnosis is crucial for controlling asthma, as it can prevent symptom worsening and reduce the risk of complications. The medical community has established several standardized diagnostic tools and procedures, such as the diagnostic steps recommended by the Global Initiative for Asthma (GINA). When diagnosing, factors such as the patient's age, symptom frequency, and severity are considered, and examination items are adjusted based on individual differences.

Clinical Assessment

Clinical assessment is the foundation of asthma diagnosis. Doctors will inquire in detail about the patient's symptom characteristics and onset patterns. Key points include the frequency of wheezing, triggers during attacks (such as cold air, allergen exposure, or post-exercise), and the response to treatment. For example, symptom relief after using bronchodilators may support an asthma diagnosis.

During physical examination, doctors will pay attention to abnormal breath sounds, such as prolonged expiration, wheezing, or crackles. These auscultation findings may be related to airway obstruction or inflammation. Additionally, observing the patient's breathing pattern during examination, such as whether there is labored breathing or involvement of accessory respiratory muscles, can provide diagnostic clues.

Medical Tests and Procedures

Pulmonary function testing is a key objective assessment for asthma. Peak expiratory flow (PEF) measurement can assess the patient's maximum expiratory flow rate at a given moment. Significant diurnal variation or improvement after treatment may suggest asthma. Moreover, a reduced ratio of forced expiratory volume in one second (FEV1) to forced vital capacity (FVC), especially during symptomatic episodes, is of important diagnostic value.

  • Bronchial challenge test: Induces airway constriction by inhaling agents (such as histamine or methacholine). A decrease in FEV1 of more than 20% is considered a positive response.
  • Bronchodilator test: After administering bronchodilators like salbutamol, an increase in FEV1 of more than 12% and an absolute increase of 200 mL supports the diagnosis of reversible airway obstruction.

Imaging examinations are less commonly used as first-line tools in asthma diagnosis, but chest X-rays can exclude other lung diseases such as pneumonia or pneumothorax. In cases of suspected complications (e.g., asthma-sinusitis comorbidity), a head CT scan may be arranged. Allergen testing (such as skin prick tests or serum-specific IgE measurements) is used to evaluate the impact of allergic factors on asthma exacerbations.

Screening and Assessment Tools

Asthma screening tools are often used in primary healthcare settings. Questionnaires such as the "Asthma Control Test (ACT)" include 7 questions; a score below 20 indicates uncontrolled disease. For pediatric patients, age-appropriate versions like the "Childhood Asthma Control Test (C-ACT)" are used.

Daily monitoring with a peak flow meter can track lung function changes. Patients can measure PEF at home and draw variation curves. If PEF fluctuates more than 15% within 24 hours or shows more than 20% variation over a week, it may reflect uncontrolled asthma. These long-term tracking data are highly valuable for adjusting treatment plans.

Differential Diagnosis

Differential diagnosis involves excluding diseases with similar symptoms to asthma. Chronic obstructive pulmonary disease (COPD) usually involves irreversible airway obstruction, while cardiogenic wheezing may be triggered by emotional stress but lacks airway inflammation markers. Additionally, gastroesophageal reflux disease (GERD) causing reflux cough or heart failure leading to pulmonary edema can mimic asthma symptoms.

  • Chronic cough syndrome: Symptoms resemble asthma but lung function tests are normal; challenge tests are needed to exclude.
  • Vasospastic wheezing: Exercise-induced wheezing may be related to airway hyperreactivity and should be confirmed with post-exercise lung function tests.
  • Drug-induced airway constriction: Certain beta-blockers may induce symptoms similar to asthma; medication history should be evaluated.

In children, differentiation from croup or foreign body obstruction is necessary. Croup is common in young children, with symptoms worsening at night and accompanied by stridor, while foreign body obstruction has a clear history of inhalation. These differential processes help prevent misdiagnosis and guide appropriate treatment strategies.

Importance of Early Diagnosis

Early diagnosis allows for timely initiation of control therapy, slowing airway remodeling processes. Long-term undiagnosed asthma may lead to permanent structural changes such as airway smooth muscle hypertrophy or mucous gland hyperplasia, which worsen disease severity. Early use of anti-inflammatory medications (such as inhaled corticosteroids) can reduce the risk of these structural changes.

In pediatric patients, failure to seek medical attention during early symptoms may result in missing the optimal treatment window during growth and development. Poorly controlled asthma in children can lead to activity limitations, sleep disturbances, and academic decline, all of which can be alleviated through early diagnosis. Adult patients may be misdiagnosed with chronic cough or cardiac disease, leading to unnecessary invasive tests or treatments.

Studies show that early diagnosis can reduce the frequency of acute attacks by over 40% and decrease emergency visits. Regular monitoring of PEF values and symptom diaries can establish real-time feedback mechanisms with healthcare providers, further improving diagnostic and treatment accuracy.

 

Frequently Asked Questions

How to differentiate between asthma and other respiratory diseases with similar symptoms?

Symptoms of asthma such as wheezing, cough, and dyspnea can be confused with chronic obstructive pulmonary disease or cardiac diseases. Doctors usually confirm the diagnosis through pulmonary function tests, peak expiratory flow monitoring, and response to anti-inflammatory treatment to exclude other similar diseases.

What role does allergy testing play in asthma diagnosis?

Allergy testing helps identify key allergens that trigger asthma attacks, but not all asthma patients have allergic histories. This testing mainly aids in developing personalized prevention strategies, such as avoiding specific allergens or combining allergy immunotherapy.

Why is long-term symptom monitoring critical for asthma diagnosis?

Doctors evaluate asthma control by continuously tracking symptom severity, nocturnal symptom frequency, and medication use. This data helps adjust treatment plans and prevents misdiagnosis of chronic cough or other respiratory issues as asthma.

How do environmental factors influence the diagnosis process of asthma?

Exposure to environmental factors such as tobacco smoke, air pollution, or occupational chemicals can exacerbate asthma symptoms or trigger acute attacks. During diagnosis, doctors will inquire about the patient's living environment to exclude other potential causes and recommend environmental improvements.

What are the challenges in diagnosing asthma in children?

Young children may find it difficult to cooperate with pulmonary function tests, complicating diagnosis. Physicians often rely on symptom history, family history, and clinical observation, combined with non-invasive tests like fractional exhaled nitric oxide (FeNO), to improve diagnostic accuracy in young children.

Asthma