Esomeprazole is a proton pump inhibitor (PPI) primarily used to suppress gastric acid secretion. This medication works by blocking the proton pumps in the parietal cells of the stomach lining, effectively reducing acid production and is suitable for treating various gastrointestinal diseases caused by excess stomach acid.
Common clinical uses include gastric ulcers, duodenal ulcers, gastroesophageal reflux disease (GERD), and Zollinger-Ellison syndrome. Its effects are long-lasting and potent, providing rapid symptom relief and promoting ulcer healing.
The generic name of this drug is Esomeprazole. Major brand names include:
Different formulations (capsules, oral suspensions, injections) may have different brand names. Confirm medication information provided by the pharmacist before use.
It belongs to the class of proton pump inhibitors (PPIs), which selectively inhibit the H+/K+-ATPase enzyme in the gastric parietal cells, fundamentally blocking acid secretion. Compared to other antacids or H2 receptor antagonists, its acid suppression effect is more sustained and longer-lasting.
Mainly indicated for:
In certain cases, it is also used to treat Zollinger-Ellison syndrome, a condition characterized by excessive gastric acid secretion.
Mild side effects include:
Serious side effects requiring immediate medical attention:
Contraindications: Contraindicated in individuals allergic to Esomeprazole or its excipients. Patients with severe liver disease should have dosage adjustments, as reduced metabolism may increase side effect risks.
Use during pregnancy and lactation should be cautious. Current studies suggest potential risks to the fetus (FDA pregnancy category C). Long-term use exceeding one year may increase risks of gastrointestinal infections or vitamin B12 deficiency.
Using with anticoagulants (such as Warfarin) may increase bleeding risk; regular INR monitoring is recommended. Combining with antifungal medications (like Ketoconazole) may reduce their efficacy.
Avoid concurrent use with antiepileptic drugs (such as Phenytoin), as it may prolong their half-life. Inform your doctor about any supplements like iron or vitamin preparations, as their absorption may be affected by acid suppression.
Oral capsule formulations are typically taken once or twice daily, preferably 30 minutes before meals for optimal absorption. Initial doses for gastric ulcers or reflux are usually 20-40 mg/day, with higher doses for severe symptoms.
Injectable forms must be administered by healthcare professionals and are used for patients unable to take oral medication. When treating Helicobacter pylori infection, it should be combined with antibiotics, following the doctor’s instructions to complete the full course to prevent resistance.
If a dose is missed, take it as soon as possible. If it is close to the next scheduled dose, skip the missed dose. Do not double doses to make up for missed ones, to avoid gastrointestinal discomfort.
Overdose may cause severe diarrhea, dizziness, or altered consciousness; seek immediate medical attention. Emergency measures include gastric lavage, activated charcoal, or supportive treatment. Long-term overdose can lead to excessive acid suppression, increasing the risk of gastric infections.
Now, the user requests five FAQ questions about Esomeprazole in Traditional Chinese, formatted as per their specifications. They want questions that are practical and cover different aspects such as timing of medication, side effect management, drug interactions, lifestyle advice, and long-term use considerations.
Each question should be unique and not overlap with the basic information already covered in the main article. The answers should be concise, no more than four sentences, accurate, and based on the latest medical guidelines. The answers should be in Traditional Chinese, using formal and clear language, and should include relevant details such as when to take the medication, how to manage side effects, potential interactions, lifestyle tips, and precautions for long-term use.
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