Treatment of Rosacea

The goal of rosacea treatment is to alleviate redness and swelling, reduce skin inflammation, and prevent symptom progression. Treatment strategies should be tailored based on the severity of the patient's symptoms, skin type, and lifestyle, typically combining pharmacological and non-pharmacological methods. Physicians will adjust the plan according to individual needs to achieve long-term control.

The treatment process requires close cooperation between the patient and healthcare team, with regular follow-up and medication adjustments. Current treatment options include medication therapy, physical therapy, and lifestyle modifications, employing a multifaceted approach to enhance treatment efficacy.

Current Treatment Options

Modern medicine offers various treatment choices, mainly divided into drug therapy, physical therapy, and lifestyle management. Drug treatment primarily involves anti-inflammatory medications, used topically or orally to control symptoms. Physical therapies such as laser or light therapy can improve vascular dilation and redness, while lifestyle adjustments can reduce triggers and slow disease progression.

For patients with prominent blood vessels, Pulsed Dye Laser (PDL) can selectively destroy dilated vessels, shortening treatment cycles. Severe edema cases may require oral immunomodulators, but with strict monitoring for side effects. Recent research has developed combination therapies integrating medication and laser treatments to enhance skin barrier repair.

Pharmacological Treatment

Topical Medications

Topical antibiotics such as Metronidazole Gel are first-line options, with anti-bacterial and anti-inflammatory effects that can reduce redness and papules. 1% Ivermectin Gel targets the mite hypothesis, suitable for patients resistant to antibiotics. Topical retinoids (e.g., Adapalene Gel) can promote keratinocyte turnover but may cause initial irritation.

  • Metronidazole Gel: Apply 1-2 times daily, requiring several weeks of continuous use for effect
  • Ivermectin Gel: Use 3 times weekly, avoiding contact with delicate skin around the eyes
  • 0.75% Brimonidine Gel: Significantly improves vascular dilation

Oral Medications

Oral antibiotics such as Doxycycline or Minocycline effectively suppress inflammatory responses. It is recommended to use low doses for long-term management to prevent antibiotic resistance. Severe inflammatory cases may require short-term oral corticosteroids, but only under careful supervision to minimize side effects.

New biologic agents like anti-IL-17 monoclonal antibodies are currently in clinical trials and may offer new options for refractory rosacea. Physicians will develop personalized medication plans based on the extent of skin damage.

Non-Pharmacological Therapies

Light and Laser Therapy

Pulsed Dye Laser (PDL) specifically targets erythema and vascular dilation, inducing selective photothermolysis to constrict blood vessels. Intense Pulsed Light (IPL) can address multiple skin issues simultaneously, requiring multiple sessions for optimal results. 1064nm lasers are suitable for deep vascular repair, especially for dilated vessels on the neck.

  • Post-laser treatment, skin hydration and sun protection are essential to prevent rebound effects
  • Interval between IPL sessions is recommended at 4-6 weeks, with a total of 3-5 sessions per course

Surgical and Cosmetic Procedures

Severe nasal tissue hypertrophy (rhinophyma) may require minimally invasive surgical correction. Microneedling can promote collagen regeneration and improve skin texture. Cosmetic-grade skincare ingredients such as niacinamide and ceramides can strengthen the skin barrier and reduce recurrent symptoms.

Lifestyle Management

Daily skincare is a vital component of treatment. Gentle cleansing to avoid damaging the skin barrier is recommended, using soap-free cleansers. Sunscreen with at least SPF30 should be applied regularly to block UV triggers.

  • Avoid high-temperature environments: hot foods, saunas may trigger flushing
  • Dietary adjustments: reduce intake of spicy foods, alcohol, and fermented products
  • Stress management: techniques such as mindfulness training or regular exercise can help alleviate symptoms

Future Directions in Treatment

Gene therapy and microbiome modulation are research hotspots, aiming to block inflammatory signaling pathways. Biologics targeting overactivation of Th17 cells are in clinical trials and may become third-line treatments.

Personalized medicine trends include genetic testing to help physicians predict drug responses and develop more precise treatment plans. New anti-inflammatory drugs focusing on JAK-STAT pathway inhibitors are expected to reduce the reliance on traditional antibiotics.

When to Consult a Specialist

If symptoms interfere with daily life, such as persistent redness or new skin lesions, immediate medical evaluation is recommended. Worsening symptoms after self-medication or the appearance of edema-type lesions (papulopustular lesions) require diagnosis by a dermatologist. Before starting new medications or laser treatments, discuss risks and benefits with your doctor.

If ocular symptoms such as conjunctivitis or corneal ulcers occur, referral to an ophthalmologist is necessary. When treatment effects are inadequate, re-evaluation of medication cycles or combination therapies may be needed, and professional assessment is crucial.

 

Frequently Asked Questions

How can I identify triggers for rosacea and avoid them?

Triggers include environmental temperature changes, spicy foods, alcohol, stress, hot foods or drinks. Patients can keep a diary to record symptoms and daily activities, gradually eliminating behaviors that provoke redness or inflammation, and avoiding known irritants whenever possible.

What factors should be considered when choosing topical or oral medications?

The choice depends on the severity of skin symptoms, affected areas (such as central facial redness or papules and nodules), and patient tolerance. Mild symptoms may be managed initially with topical antibiotics or vasoconstrictors; moderate to severe or recurrent cases may require oral antibiotics or isotretinoin. Consultation with a dermatologist is recommended for personalized decision-making.

Should daily skincare routines be adjusted during treatment?

Yes, use fragrance-free, low-irritation skincare products, avoiding alcohol or fruit acid-containing items. Gentle, soothing moisturizers are preferred, and avoid vigorous rubbing or massage to prevent exacerbating vascular dilation or inflammation.

How significant is UV exposure for rosacea, and how can I protect myself?

UV rays can worsen redness and vascular dilation. Daily use of broad-spectrum physical sunscreens (such as zinc oxide) along with physical barriers like umbrellas and wide-brimmed hats is recommended. If taking photosensitizing medications like isotretinoin, extra caution is needed to avoid sun exposure.

Can rosacea be transmitted through contact?

Rosacea is not contagious. Its causes are related to abnormal vascular dilation, imbalance of certain skin microbiota (such as Demodex mites), or immune responses, and it does not spread through contact or air. However, psychological stress from the condition may affect symptoms, so emotional management is important.

Rosacea