Treatment of Gallstones

The goal of gallstone treatment is to relieve symptoms, prevent complications, and restore the patient's normal life. Treatment strategies are usually tailored based on the size, location, severity of symptoms, and overall health of the patient. Mild symptoms may only require observation and lifestyle adjustments, while patients with acute attacks or recurrent episodes may need surgical or pharmacological intervention.

Modern medicine offers various treatment options, including medication dissolution, endoscopic surgery, and laparoscopic surgery. Physicians will evaluate the stone composition (such as cholesterol stones or pigment stones) to select the most appropriate approach. Patients need regular follow-up and should cooperate with medical advice to adjust dietary habits to reduce the risk of recurrence.

Current Treatment Options

Gallstones are classified into two main categories: symptomatic and asymptomatic. For asymptomatic stones larger than 3 cm, physicians may recommend active treatment to prevent future complications. The main treatment methods include:

  • Observation and waiting: suitable for small asymptomatic stones, with ultrasound follow-up every 6-12 months
  • Pharmacotherapy: suitable for patients unable to undergo surgery or whose stone composition is amenable to medication
  • Endoscopic treatment: used in emergency situations such as acute obstruction or concurrent pancreatitis
  • Surgical treatment: for patients with recurrent episodes or concurrent cholecystitis

Pharmacological Treatment

Medication mainly targets cholesterol stones, but its efficacy is slow with a success rate of about 10-30%. Common medications include:

  • Ursodeoxycholic acid (UDCA): taken orally daily, requiring continuous use for over 6 months, may reduce stone size but cannot completely dissolve stones
  • Pain relievers: such as non-steroidal anti-inflammatory drugs (NSAIDs) for acute pain control, but long-term use should be avoided
  • Antibiotics: used only in cases of acute cholecystitis with infection, commonly including cephalosporins and fluoroquinolones

Limitations of pharmacotherapy include long treatment duration, higher costs, and potential side effects such as liver function abnormalities. Therefore, most guidelines recommend medication as a second-line option, suitable only for high-risk surgical patients.

Non-Pharmacological Therapies

Endoscopic and surgical treatments are direct methods to remove stones, with options based on patient condition:

Endoscopic Retrograde Cholangiopancreatography (ERCP)

This technique is suitable for stones obstructing the bile duct. It involves inserting an endoscope through the mouth into the duodenum, using electrocautery or balloon dilation to extract the stones. Success rates are as high as 80-90%, but complications such as pancreatitis or perforation may occur.

Laparoscopic Cholecystectomy

The most common treatment currently, involving removal of the entire gallbladder through 3-4 small incisions. Minimally invasive surgery has a short recovery time and a complication rate below 5%, but patients may experience temporary digestive discomfort after complete removal.

Extracorporeal Shock Wave Lithotripsy (ESWL)

Uses high-frequency vibrations to break stones, but its effectiveness is limited and may cause stone migration leading to bile duct obstruction. Currently, it is mainly used for elderly patients who cannot undergo surgery.

Lifestyle Management

Dietary adjustments are an important part of treatment. Patients are advised to:

  • Limit high-fat, high-cholesterol foods (such as fried foods and animal organs)
  • Increase dietary fiber intake (such as whole grains and vegetables)
  • Maintain a moderate weight and avoid rapid weight loss that can trigger stone formation

Regular exercise can improve bile composition; it is recommended to do 30 minutes of aerobic activity daily. Avoid long fasting periods, and choose low-fat, high-protein meals to reduce gallbladder over-contraction and pain.

Future Treatment Directions

Current research focuses on developing non-invasive treatments and personalized medicine. Emerging technologies include:

  • Focused ultrasound lithotripsy: uses focused energy to precisely break stones, reducing tissue damage
  • Gene therapy: developing targeted drugs for specific causes such as hereditary peroxidase enzyme deficiency
  • Artificial bile acid metabolism regulators: new compounds under development to promote stone dissolution

Clinical trials are also exploring the use of specific probiotics to modulate gut flora, potentially improving bile composition. However, these technologies are not yet widespread and require careful assessment of risks and benefits.

When to Consult a Specialist

Seek medical attention immediately if you experience:

  • Severe right upper abdominal pain accompanied by fever or jaundice
  • Vomiting with nausea lasting more than 6 hours
  • Ultrasound showing stones larger than 2 cm in diameter

High-risk groups such as those with diabetes, obesity, or a family history should undergo annual ultrasound examinations. Physicians may adjust treatment strategies based on stone location (e.g., common bile duct) or other conditions (e.g., liver cirrhosis).

 

Frequently Asked Questions

Will all patients experience digestive problems after gallbladder removal surgery?

Not all patients will have obvious symptoms. Some may experience diarrhea or bloating initially after surgery, but most gradually adapt over weeks to months. If symptoms persist or worsen, consult a doctor for evaluation and possible dietary or medication adjustments.

What dietary principles should gallstone patients follow if they choose not to undergo surgery for now?

It is recommended to avoid high-fat, high-cholesterol, and high-calorie foods such as fried items, fatty meats, and full-fat dairy products. Eating smaller, more frequent meals and increasing fiber intake can help reduce gallbladder burden. If symptoms occur frequently, surgical treatment should be considered.

Is extracorporeal shock wave lithotripsy safe and effective for gallstones?

ESWL may be effective for certain types of gallstones, but its success rate is lower than gallbladder removal, and there is a risk of stone obstruction or infection. This method is usually suitable for patients who cannot tolerate surgery or have specific stone locations, and should be decided upon after medical evaluation.

Why do gallstone patients need long-term medication during stone dissolution therapy?

Medications for stone dissolution require long-term use (possibly several years) to dissolve stones, with better efficacy for cholesterol stones. Pigment stones are usually unresponsive. Regular follow-up is necessary during treatment, and stones may recur after stopping medication. Patients should discuss risks and benefits thoroughly with their doctors.

After laparoscopic cholecystectomy, is there a need to restrict exercise or adopt specific postures?

Short-term avoidance of strenuous activity for about 2-4 weeks is recommended, but daily activities can gradually resume. Wound healing periods should avoid heavy lifting, but moderate walking can help prevent thrombosis. Specific restrictions should be tailored based on individual recovery and medical advice.

Gallstones