Blood tests

Overview of the Procedure

Blood testing is a fundamental and essential diagnostic procedure that evaluates the body's health status and disease indicators through the analysis of blood components. This non-invasive test can quickly provide key data such as red blood cell count, white blood cell count, and liver and kidney function. It is commonly used in routine health screenings, chronic disease monitoring, and acute symptom assessment. The process involves blood collection, separation of plasma and cellular components, and subsequent quantitative analysis using instruments or chemical reagents.

Types of Tests and Mechanisms

Blood tests can be categorized into three main types:

  • Complete Blood Count (CBC): Measures blood cell quantity and morphology to assess infections, anemia, or hematologic disorders.
  • Biochemical Tests: Analyzes metabolic indicators such as blood glucose, liver and kidney enzymes, and lipids to aid in diagnosing diabetes, hepatitis, or renal failure.
  • Special Tests: Includes coagulation function tests, autoimmune antibody screening, or genetic blood disorder analysis.

The mechanisms primarily involve optical sensors, electrochemical reactions, or fluorescence labeling techniques, converting blood components into numerical data, which are then compared to normal reference values for abnormality interpretation.

Indications

Blood tests are suitable for various clinical scenarios, including:

  • Routine health check-ups to monitor basic health indicators.
  • Screening for unknown causes of symptoms such as fever or headache.
  • Long-term monitoring of chronic conditions like diabetes and hypertension.
  • Pre- and post-operative coagulation assessment and risk evaluation.

Additionally, prenatal testing during pregnancy, cancer tracking, and monitoring drug side effects also utilize this test.

Usage and Dosage

The test is usually performed by healthcare personnel who draw 5-10 milliliters of blood from the antecubital vein; in special cases, fingertip blood sampling may be used. The collected blood must be immediately sent to the laboratory, where it is divided into different anticoagulant reagent tubes according to the test items. The concept of dosage does not apply to this test, but fasting (8-12 hours) is required for tests such as blood glucose and lipids.

Benefits and Advantages

Blood testing offers the following advantages:

  • Non-invasive and relatively low cost, allowing repeated testing to track changes.
  • A single test can cover dozens of indicators, providing comprehensive physiological information.
  • Results are objectively quantified, enabling quick assistance in diagnosis formulation.

For example, abnormal white blood cell counts can immediately suggest infection or leukemia, and elevated liver enzymes can detect early liver damage.

Risks and Side Effects

The vast majority of patients only experience local pain or bruising, with severe complications being extremely rare. Potential risks include:

  • Infection or persistent bleeding at the puncture site (especially in those with coagulation disorders)
  • Serum sickness-like reactions (very rare)
  • Vasovagal syncope (more common in individuals with high needle phobia)

Important Warning: If bleeding persists after puncture or signs of infection such as fever, redness, or swelling occur, immediate medical attention should be sought.

Precautions and Contraindications

Special populations should take extra caution:

  • Patients with bleeding disorders should inform healthcare providers in advance.
  • Those taking anticoagulants (e.g., warfarin) may need to adjust medication timing.
  • Patients with coagulation abnormalities should have the procedure performed by experienced medical staff.

Contraindications include severe uncontrolled coagulation disorders and unhealed puncture site infections. Avoid smoking, alcohol, and vigorous exercise 24 hours before the test to ensure accurate data.

Interactions with Other Treatments

Certain medications may affect test results:

  • Steroids may cause elevated blood glucose and falsely increase white blood cell counts.
  • Antibiotics may interfere with liver enzyme measurements.
  • Herbal supplements may influence coagulation times.

Patients should proactively inform healthcare providers of all medications and supplements they are using before testing. The physician will adjust the timing of the test or medication dosage accordingly.

Treatment Efficacy and Evidence

Blood tests are regarded as the "gold standard" diagnostic tool in clinical medicine, with accuracy and reproducibility validated through decades of research. For example:

  • Blood glucose testing has over 95% accuracy in diagnosing diabetes.
  • Carcinoembryonic antigen (CEA) is highly sensitive for colorectal cancer follow-up.
  • Cardiac enzyme tests are critical in diagnosing acute myocardial infarction.

Global medical guidelines consistently list blood tests as the first-line diagnostic tool, with data often serving as indicators for further imaging or tissue examinations.

Alternatives

When blood testing is not feasible, consider the following alternatives:

  • Urinalysis: Used for preliminary screening of kidney diseases or infections.
  • Imaging tests: Such as ultrasound to assess organ structure abnormalities.
  • Genetic testing: For diagnosing specific hereditary blood disorders.

However, these methods cannot comprehensively replace the breadth and immediacy of blood tests and are usually used as auxiliary diagnostic tools.

 

Frequently Asked Questions

What preparations are needed before a blood test?

It is recommended to fast for 8 to 12 hours before the test to avoid eating that could affect blood glucose or lipid results. A small amount of water is generally allowed, but large quantities should be avoided to prevent dilution of blood components. If you are taking medication, consult your doctor whether to suspend or adjust the timing of medication.

How should I handle local bruising or bleeding after a blood test?

If subcutaneous bruising occurs after blood draw, gently press the puncture site with a clean gauze for 10-15 minutes and apply ice to reduce swelling. If bleeding persists or bruising enlarges, seek medical attention promptly to check coagulation function and rule out underlying blood disorders.

Does abnormal test results necessarily indicate serious illness?

A single abnormal value does not necessarily mean a serious disease; it could be caused by recent diet, menstrual cycle, or environmental factors during blood collection. The doctor will interpret the data based on clinical symptoms, other test results, and personal medical history, and may recommend re-testing or further examinations if necessary.

Do patients undergoing chemotherapy or long-term medication need to adjust the frequency of blood tests?

Patients on chemotherapy or immunosuppressants need regular monitoring of blood cell counts and liver and kidney functions, often monthly or more frequently. The doctor will adjust the testing interval based on the medication type, efficacy, and patient response to ensure treatment safety.

Why do reference ranges in blood test reports vary?

Different laboratories may have different normal value ranges due to variations in testing methods, instruments, or reference standards. Age, gender, and ethnic differences can also influence baseline values. The doctor will interpret the data considering the overall condition of the patient to avoid misjudgment based on a single index.