Etodolac is a non-steroidal anti-inflammatory drug (NSAID) primarily used to relieve pain and inflammation caused by acute and chronic inflammatory conditions. It works by inhibiting prostaglandin synthesis within the body, thereby providing anti-inflammatory, analgesic, and antipyretic effects. Common clinical applications include treatment of osteoarthritis, rheumatoid arthritis, and pain management after surgery or acute trauma.
Compared to other NSAIDs, Etodolac has relatively lower gastrointestinal irritation but may have effects on the cardiovascular system. Before use, it should be evaluated by a physician considering the patient’s overall health status, especially in those with cardiovascular or renal impairments.
The generic name of this medication is Etodolac. Common brand names in Taiwan and Hong Kong include:
Available in various formulations including capsules, extended-release tablets, and topical gels.
Etodolac belongs to the 2-arylpropionic acid derivatives within the NSAID class. Its pharmacological action mainly involves inhibiting cyclooxygenase (COX), reducing the production of inflammatory mediators, and thereby alleviating pain and swelling.
Primary indications include:
Physicians may prescribe it for other similar short-term treatments based on individual case needs, but strict adherence to prescription guidelines is required.
Minor side effects may include:
These symptoms usually diminish as the body adjusts to the medication.
Serious side effects require immediate discontinuation and medical attention:
If these symptoms occur, seek medical attention immediately.
Contraindications:
This medication carries a black box warning from the U.S. FDA, indicating that long-term use may increase the risk of heart disease and stroke. Patients with renal impairment may experience edema or worsening kidney function, requiring regular blood and urine monitoring.
Concurrent use with anticoagulants (such as warfarin) may increase bleeding risk. Combining with diuretics may reduce the antihypertensive effects of the latter. Using with other NSAIDs or corticosteroids increases the risk of gastrointestinal side effects.
Blood sugar levels should be monitored when taking antidiabetic medications, as NSAIDs may affect glucose control. Consult a healthcare provider before using herbal supplements like ginkgo or fish oil.
The typical adult dose is 400-600 mg per dose, 2-3 times daily. For acute pain, an initial loading dose of 1000 mg may be given. Extended-release tablets should be swallowed whole and not chewed to prolong the drug’s effect.
It is recommended to take with food to reduce gastrointestinal irritation, but if rapid pain relief is needed, it can be taken on an empty stomach under medical advice. Do not adjust the dose independently; follow the prescription strictly.
If a dose is missed and it is within 4 hours of the scheduled time, take it as soon as remembered and adjust the subsequent dosing interval accordingly. If more than 4 hours have passed, skip the missed dose and resume the regular schedule. Do not double doses to make up for missed ones.
Acute overdose may cause severe abdominal pain, confusion, seizures, or respiratory depression. If overdose is suspected, immediately:
Severe cases may require gastric lavage or activated charcoal to absorb unabsorbed drug. Supportive treatment will be based on blood drug levels and clinical condition. Do not attempt self-treatment.
Now, I will generate five frequently asked questions about Etodolac in Traditional Chinese, following user-specified formats and covering different aspects such as usage timing, side effects, drug interactions, safety in pregnancy, and overdose response. These questions will be unique, practical, and avoid basic definitions. I will ensure they are relevant for patients or caregivers and provide clear, concise answers. First, I will confirm the Chinese translation of Etodolac, which is commonly translated as “乙托洛酸,” and check for other common names. The questions will include topics like whether to take with food, liver function monitoring, interactions with other painkillers, safety during pregnancy or breastfeeding, and what to do in case of overdose.
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