Pain medication:

MAGIC MUSHROOMS INGREDIENT
BENEFICIAL TO CANCER PATIENTS

Researchers find psilocybin improved
the anxiety and depression of terminal
cancer patients for up to six months.

Psilocybin is illegal and listed in the
same class of drugs as LSD and
heroin, according to the Department of
Justice.
Researchers conducted extensive
investigations of hallucinogens in the
1950s and 1960s. By the early 1970s,
however, political and cultural
pressures forced the cessation of all
projects.
This clinical trial  reexamined a
potentially promising clinical
application of hallucinogens in the
treatment of anxiety relative to
advanced-stage cancer.
Study subjects were acting as their
own control,and were given a
moderate dose (0.2 mg/kg) of
psilocybin.
Safe physiological and psychological
responses were documented during
treatment sessions. There were no
clinically significant adverse event. The
State-Trait Anxiety Inventory trait
anxiety subscale demonstrated a
significant reduction in anxiety at 1 and
3 months after treatment. The Beck
Depression Inventory revealed an
improvement of mood that reached
significance at 6 months; the Profile of
Mood States identified mood
improvement after treatment with
psilocybin that approached but did not
reach significance.
The trial was conducted at the Los
Angeles Biomedical Research Institute
at Harbor-UCLA Medical Center in
collaboration with the Heffter Research
Center, Zürich, Switzerland.

Clinicaltrials.gov Identifier:
NCT00302744



MORPHINE PLUS OXYCODONE IV IS
BETTER THAN MORPHINE ALONE
Combination Of Morphine Plus
Oxycodone IV Demonstrates Improved
Analgesia And Tolerability Compared
To IV Morphine.
QRxPharma Limited has announced
today positive results of its Phase 2
comparative proof-of-concept study to
evaluate the efficacy and safety of its
IV (intravenous) formulation of
morphine plus oxycodone versus IV
morphine alone for the treatment of
moderate to severe post-operative
pain in patients following hip
replacement surgery. The main
findings demonstrated that
QRxPharma's formulation of MoxDuo
IV resulted in fewer side effects and
offered better pain relief than
morphine alone.

This double blind, active controlled,
investigator initiated study was
conducted in Germany in collaboration
with QRxPharma at the Cologne-
Merheim Medical Center.




AN IMPROVED VERSION OF
MORPHINE
Morphine-6-Glucuronide (M6G) is a
new morphine derivative under
development by biopharmaceutical
company PAION. Development of M6G
was initiated by CeNeS
Pharmaceuticals, which PAION
acquired in June 2008. CeNeS was a
UK company.
Morphine is a highly potent opioid drug
and one of the most effective
analgesics currently available.
However, it is associated with a
number of unwanted side effects and
is often poorly tolerated by patients.
Clinical studies in which M6G has been
compared with conventional morphine  
show that it possesses similar
analgesic efficacy, but with a
significantly improved side-effect
profile. In patients admitted  
gynaecological surgery, for example,
the incidence of nausea and vomiting
was reduced by more than 50%.  In
addition to a 50% reduction in the
incidence of nausea and vomiting
among patients receiving M6G,
incidence of respiratory depression
and sedation was also markedly lower.


TARGINACT: A PAINKILLER WITHOUT
MORPHINE'S SIDE EFFECT
by Napp Pharma. Targinact is a
medication that is not suitable for all
people who are experiencing severe
and chronic pain. Unfortunately its
primary use is with regard to treating
pain conditions such as osteoarthritis
or some forms of back pain; but only if
these conditions are responding to
painkillers that are opiate based.

Unlike morphine however, it does not
have the same effect in terms of
constipation. Thus targinact may be a
useful medication for people who find
that constipation is simply unbearable
with morphine.

Targinact is a compound of two
different ingredients, namely naloxene
and oxycodone. The oxycodone is a
very effective opioid painkiller whereas
the naloxene is known as an opioid
‘antagonist’.

The opioid painkiller works by
effectively tricking the brain into
thinking that endorphins have been
released. Endorphins are chemicals
that not only reduce pain, but they are
also known as ‘feel good’ chemicals.



NEW SUPER STRONG PAIN KILLER
MADE FROM SNAIL'S SALIVA
developed from snail spit.
Marine cone snails produce a saliva
that contains a deadly dose of peptide
toxins to help the slow-moving
creatures catch prey. They inject
passing victims with needle-like teeth
that shoot out of their mouths.

Scientists have already transformed
one of the chemicals into a pain-
reliever for humans. However, it has to
be injected directly into the spinal cord
which limits how much it can be used.

Now researchers in Australia, led by
David Craik of the University of
Queensland, have developed a form of
the painkiller that can be taken orally.

The drug could potentially
revolutionize the treatment of the most
severe forms of pain and Professor
Craik is keen to take his research
further.
  • Deep Penetrating, Long Lasting
    Pain Relief From: Arthritis, Sore
    Muscles & Joints, and Back Pain.
  • Greaseless
  • Stainless
  • Vanishing Scent
  • Cryotherapy - The Cold Method